Durable treatment of ameloblastoma with single agent BRAFi Re: Clinical and radiographic response with combined BRAF-targeted therapy in stage 4 ameloblastoma.
نویسندگان
چکیده
Affiliations of authors: Department of Medicine (FJK) and Clinical Trials Office (AMI), University of Florida Cancer Center; Department of Radiology (WD), Department of Radiation Oncology (WMM), and Department of Pathology, Immunology, and Laboratory Medicine (RWA), University of Florida College of Medicine, Gainesville, FL. Correspondence to: Frederic J. Kaye, MD, University of Florida College of Medicine, 2033 Mowry Rd, CGRC Rm 364, Gainesville, FL 32610 (e-mail: [email protected]).
منابع مشابه
BRAF inhibitor treatment of primary BRAF-mutant ameloblastoma with pathologic assessment of response.
OBJECTIVE Molecular characterization of ameloblastoma has indicated a high frequency of driver mutations in BRAF and SMO. Preclinical data suggest that Food and Drug Administration-approved BRAF-targeted therapies may be immediately relevant for patients with ameloblastoma positive for the BRAF V600E mutation. METHODS A neoadjuvant treatment regime of dabrafenib was given to a patient with re...
متن کاملRegarding BRAF-inhibitor therapy of primary ameloblastoma.
To the Editor: Tan et al. describe the use of dabrafenib in the management of a primary intraosseous BRAF V600E mutant ameloblastoma prior composite surgical resection, as a single case report. Although this potentially represents a novel approach to management for some cases of ameloblastoma, inclusion of several additional data points would be instructive. At initial presentation, the 4-cm ma...
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Unicystic ameloblastoma is a tumor of odontogenic origin. It is not a rare neoplasm and most often the lesion is asympthomatic. However, large lesions may cause painless swelling of the jaws. Here we report a case of unicystic ameloblastoma with pain, swelling of the posterior jaws along with teeth mobility. Samples of incisional biopsy of the lesion and also interaoperative frozen section were...
متن کاملActivating FGFR2-RAS-BRAF mutations in ameloblastoma.
PURPOSE Ameloblastoma is an odontogenic neoplasm whose overall mutational landscape has not been well characterized. We sought to characterize pathogenic mutations in ameloblastoma and their clinical and functional significance with an emphasis on the mitogen-activated protein kinase (MAPK) pathway. EXPERIMENTAL DESIGN A total of 84 ameloblastomas and 40 non-ameloblastoma odontogenic tumors w...
متن کاملHigh frequency of BRAF V600E mutations in ameloblastoma
Ameloblastoma is a benign but locally infiltrative odontogenic neoplasm. Although ameloblastomas rarely metastasise, recurrences together with radical surgery often result in facial deformity and significant morbidity. Development of non-invasive therapies has been precluded by a lack of understanding of the molecular background of ameloblastoma pathogenesis. When addressing the role of ERBB re...
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ورودعنوان ژورنال:
- Journal of the National Cancer Institute
دوره 109 1 شماره
صفحات -
تاریخ انتشار 2015